Zevsildna Plus Tablet in Pakistan: The Comprehensive Guide to Sildenafil + Fluoxetine Formula

Are you searching for the ultimate medical solution for Erectile Dysfunction (Mardan Kamzori) and Premature Ejaculation (Surat-e-Anzal)? You may have encountered various options, from herbal supplements to single-ingredient tablets like Viagra. However, for men seeking a dual-action therapy that addresses both “Power” and “Timing” simultaneously, Zevsildna Plus has emerged as a leading pharmaceutical choice in Pakistan.

This comprehensive guide analyzes the Zevsildna Plus formula, its pricing in Pakistan, medical mechanism, dosage protocols, and critical safety information.

What is Zevsildna Plus? (The Dual-Action Formula)

Zevsildna Plus is a Fixed-Dose Combination (FDC) medication. Unlike standard timing tablets that rely on numbing agents or unverified herbs, Zevsildna Plus combines two FDA-approved active ingredients into a single film-coated tablet:

1. Sildenafil Citrate (100mg): The gold-standard treatment for Erectile Dysfunction (ED). It is the same active ingredient found in Viagra.
2. Fluoxetine Hydrochloride (20mg/40mg): A Selective Serotonin Reuptake Inhibitor (SSRI). While widely known as the antidepressant Prozac, it is clinically proven to significantly delay the ejaculatory reflex.

Why This Combination?

Research indicates that nearly 30% of men suffering from ED also experience PE. The two conditions often fuel each other: the anxiety of finishing too quickly can kill an erection, and the struggle to maintain an erection can lead to rushing the act.

• Sildenafil handles the Hydraulics: It ensures blood flow for a rock-hard erection.
• Fluoxetine handles the Control: It increases serotonin in the brain, raising the threshold for ejaculation.

This synergy breaks the cycle of performance anxiety, providing what is colloquially known as “Complete Control” in bed.

Mechanism of Action: How It Works in the Body

To understand why Zevsildna Plus is effective, we must look at the pharmacology of its components.

1. The Sildenafil Engine (For Hardness)

Sildenafil works by inhibiting an enzyme called Phosphodiesterase Type 5 (PDE5). Under normal conditions, sexual stimulation releases Nitric Oxide (NO), which relaxes the blood vessels in the penis. PDE5 breaks down the chemical messengers that keep these vessels open.

• Action: By blocking PDE5, Sildenafil allows the blood vessels to remain relaxed and open for longer durations.
• Result: Enhanced blood flow and a sustained erection.
• Important Note: Sildenafil requires sexual stimulation to work. It is not an “auto-erection” pill; the brain must still be aroused.

2. The Fluoxetine Regulator (For Timing)

Fluoxetine works on the Central Nervous System. Ejaculation is a reflex controlled by serotonin levels. Low serotonin availability is often linked to rapid ejaculation.

• Action: Fluoxetine blocks the reuptake of serotonin, keeping it active in the synaptic gap between neurons for a longer period.
• Result: This enhanced serotonergic tone delays the signal sent from the brain to the spinal cord to trigger ejaculation, effectively extending the Intravaginal Ejaculatory Latency Time (IELT).

Zevsildna Plus Uses & Key Benefits

While primarily searched for “sex timing,” the clinical applications are specific:

Dosage Guidelines and Administration

Warning: Always consult a healthcare provider before starting this medication. The following are general guidelines based on pharmaceutical standards.

How to Take

• Timing: Take one tablet approximately 1 to 3 hours before planned intercourse.

• Reasoning: Sildenafil peaks in the blood within 60 minutes, while Fluoxetine may take slightly longer to exert its acute effect on the nervous system. Taking it 1-3 hours prior ensures both drugs are at peak levels simultaneously.

• Method: Swallow whole with a full glass of water. Do not crush or chew.
• Dietary Impact: Avoid high-fat meals (like heavy biryani or nihari) before taking the tablet. Fat can delay the absorption of Sildenafil, making it take longer to kick in.

Dosage for Beginners

If you are new to Fluoxetine-based medications, users often ask about “Fluoxetine 20 mg uses.” The standard Zevsildna Plus tablet may contain 20mg or 40mg.

Start Slow: It is often recommended to start with half a tablet to assess tolerance to the Fluoxetine component, which can cause mild drowsiness or nausea in first-time users.

Side Effects and Critical Safety Warnings

Zevsildna Plus is a potent medication, not a multivitamin. It carries the side effect profile of both its active ingredients.

Common Side Effects

• Nausea & Dizziness: Caused by the combined effect of vasodilation (Sildenafil) and serotonin modulation (Fluoxetine).
• Headache & Flushing: A common reaction to increased blood flow.
• Insomnia or Drowsiness: Fluoxetine can affect sleep patterns. Some users feel alert, while others feel “Susti” (lethargy).
• Dry Mouth: A typical anticholinergic side effect of antidepressants.

Contraindications (Who Should NOT Take This)

1. Nitrate Medication (Angina Patients): This is a life-threatening contraindication. If you take nitrates (e.g., Angised, Nitroglycerin) for heart pain, NEVER take Zevsildna Plus. The combination can cause a fatal drop in blood pressure.
2. Serotonin Syndrome Risk: Do not take this if you are already using other antidepressants (SSRIs, MAOIs) or Tramadol. Accumulating too much serotonin can lead to Serotonin Syndrome, characterized by agitation, rapid heartbeat, and high fever.
3. Liver or Kidney Disease: Requires dosage adjustment under medical supervision.

Zevsildna Plus Price in Pakistan

The price of Zevsildna Plus varies because it is largely an imported item, often sourced from India (manufactured by companies like Combitic Global).

Price Comparison Table

Buying Advice:

• Authenticity: Look for the manufacturer’s seal. Imported generic strips from India often come in blister packs of 10.

Online Availability: Platforms like cure.com.pk often list these imported variants where major retail chains (like Dvago) might stick to locally registered brands.

Frequently Asked Questions (FAQs)

Is Zevsildna Plus better than “Desi” herbal sprays?

Yes, in terms of medical efficacy. Desi sprays typically use lidocaine to numb the penis, which reduces sensation and pleasure. Zevsildna Plus uses Fluoxetine to delay the reflex in the brain, allowing you to last longer without losing sensation.

Can I use Zevsildna Plus if I only have timing issues (PE)?

If you do not have Erectile Dysfunction, taking high-dose Sildenafil might be unnecessary. However, studies show the combination improves satisfaction even in men without severe ED by reducing the refractory period (recovery time between sessions). For pure PE, consult a doctor about low-dose Fluoxetine alone.

What is the Urdu name for these conditions?

• Erectile Dysfunction: Known as Mardan Kamzori or Namardi.
• Premature Ejaculation: Known as Surat-e-Anzal or Jaldi Farigh Hona.
  Zevsildna Plus is designed to treat both Surat-e-Anzal and Mardan Kamzori.

Will it work immediately?

Sildenafil works within 30-60 minutes. Fluoxetine’s acute effect on timing is generally noticed within 1-3 hours of dosing, though chronic (daily) use of Fluoxetine is often more effective for severe PE. Zevsildna is optimized for “on-demand” use.